Delivering Spatial Biology
to the Clinic

Spatial biology is revolutionizing the discipline of pathology and the practice of medicine. Cernostics is a pioneer in this field, using our spatial analytics platform for biologically aware AI to provide solutions across the precision medicine value chain from drug discovery to clinical diagnostics.

Our biologically aware AI platform delivered to the clinic the world’s first precision medicine test to predict the risk of developing esophageal cancer – one of the world’s most deadly cancers.

Learn more

Latest Presentations

See all

TissueCypher® Objectively Risk Stratifies Barrett’s Esophagus Patients with Low-Grade Dysplasia

Nicola Frei, Doctor of Medicine
Amsterdam UMC


Prediction of Progression in Barrett’s Esophagus Using a Tissue Systems Pathology Test: A Pooled Analysis of International Multicenter Studies

Prasad G. Iyer, MD, MS, FASGE, FACG
Gastroenterologist, Mayo Clinic


Delivering clinically actionable information from tissue biopsies
is difficult.

Tissue systems:

  • are highly complex
  • are composed of many cell types and tissue structures
  • can have 1000x of active genes, transcripts and expressed proteins

Clinicians need new ways to analyze, interpret and report data.

Only this revolution can change clinical practice.

Learn more

Our TissueCypher® platform brings together key components of biologically aware AI.

Multiplex assay development

Library of fluorescent immunolabeling assays with robust SOPs for clinical use

Feature generation

Automatic extraction of cellular and molecular information while allowing user-directed generation of biologically relevant features

Model building & validation

Reduction of complexity, classifier development & validation through access to scarce tissue sources and clinical outcomes

Intellectual property

>30 issued patents covering spatially resolved analytical methods and first clinical assay

We are applying our biologically aware AI platform across multiple therapeutic areas to deploy our precision medicine assay in the following areas:


  • Breast Cancer
  • Lung Cancer
  • Colorectal Cancer
  • Prostate Cancer
  • Gastric Cancer


  • Inflammatory Bowel Disease (Crohn’s and Ulcerative Colitis)
  • Pancreatic Cyst Evaluation & Pancreatic Cancer
  • NAFLD, NASH and Liver Cancer
  • Esophagitis